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RGX-104 free Acid

CAS No. 610318-54-2

RGX-104 free Acid( —— )

Catalog No. M21011 CAS No. 610318-54-2

RGX-104 free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)?.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RGX-104 free Acid
  • Note
    Research use only, not for human use.
  • Brief Description
    RGX-104 free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)?.
  • Description
    RGX-104 free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)?.
  • In Vitro
    ——
  • In Vivo
    Animal Model:NOD SCID or RAG mice injected with 1×106 SKOV3 ovarian cancer cells.Dosage:100 mg/kg.Administration:Oral administration daily for about 60 days.Result:Robustly suppressed tumor growth and progression.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    LXRβ
  • Research Area
    Cancer
  • Indication
    Lymphoma; Solid tumours

Chemical Information

  • CAS Number
    610318-54-2
  • Formula Weight
    596.08
  • Molecular Formula
    C34H33ClF3NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:130 mg/mL (218.09 mM)
  • SMILES
    C[C@H](CCOc1cccc(CC(=O)O)c1)N(Cc1cccc(C(F)(F)F)c1Cl)CC(c1ccccc1)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tavazoie M F Pollack I Tanqueco R et al. LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer[J]. Cell 2018:S0092867417315064.
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